Roseburia inulinivorans

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Roseburia inulinivorans is a Gram-variable, strictly anaerobic, motile, rod-shaped - curved bacterium. It has been detected in at least 26 gut microbiome compilation studies or metastudies. The DNA G+C content is 41.4%. Roseburia inulinivorans is often a widespread coloniser of gut. (Duncan2006)



  • This organism has been recovered from human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal. Robust growth can have positive consequences for gut health.
    • GENERAL CHARACTERISTICS (Duncan2006);
    Character Response
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 37℃.
  • ⥅
  • Substrates assimilated or utilised:
  • cellubiose; fructose; glucose; inulin; maltose; starch; acetate;
  • Active enzymes:
  • α-galactosidase; β-galactosidase; β-glucosidase;
  • ±
  • Strain-dependent active enzymes:
  • Gly arylamidase;
    • SPECIAL FEATURES (Duncan2006);
    Character Response
  • ✓
  • Metabolites produced:
  • formate; butyrate (major); lactate;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced
  • NOTES

    This is a common and important member of the human gut microbiome.

    Fuel sources used:
    It can use resistant starch, fibre, and simple sugars for energy.

    Metabolites produced:
    Our genomic analysis indicates that most members of this species can produce the following metabolites: acetate, BCAAs, butyrate, lactate, cobalamin, folate, biotin.

    Metabolites consumed:
    In addition, our genomic analysis indicates that most members of this species do not consume any reported metabolites.

    Emerging research:
    This species has been observed at reduced levels in individuals with type 2 diabetes.

  • References: [1] [2] [3]

  • Duncan, S. H., Aminov, R. I., Scott, K. P., Louis, P., Stanton, T. B., & Flint, H. J. (2006). Proposal of Roseburia faecis sp. nov., Roseburia hominis sp. nov. and Roseburia inulinivorans sp. nov., based on isolates from human faeces. International Journal of Systematic and Evolutionary Microbiology, 56(Pt 10), 2437–2441.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Roseburia Gram stain:  vr O2 Relation.:  strictly anaerobic Motility:  Swimming Morphology:  Rod - curved
    Health:   Positive
    Source:  human faeces
    DNA G+C(%):  41.4
    Opt. T:  37℃
    		Urea:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Mannose:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  neg Fructose:  + Glucose:  + Xylose:  neg Cellubiose:  + Maltose:  + Melibiose:  w Raffinose:  neg Sucrose:  w Glycerol:  neg Inulin:  + Sorbitol:  neg Starch:  + Xylan:  neg Acetate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  neg β-Glucosidase:  + β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  neg GluGluAA:  neg GlyAA:  d LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg AlkalineP:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Formate:  + Butyrate:  Major(+) Lactate:  + Indole:  neg

    References

    SPECIFIC REFERENCES FOR ROSEBURIA INULINIVORANS
  • Duncan2006 - Proposal of Roseburia faecis sp. nov., Roseburia hominis sp. nov. and Roseburia inulinivorans sp. nov., based on isolates from human faeces.
  • Borgo2017 - Microbiota in anorexia nervosa: The triangle between bacterial species, metabolites and psychological tests
  • Chua2018 - Intestinal Dysbiosis Featuring Abundance of Ruminococcus gnavus Associates With Allergic Diseases in Infants
  • DeAngelis2013 - Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified
  • Debyser2016 - Faecal proteomics: A tool to investigate dysbiosis and inflammation in patients with cystic fibrosis
  • Dong2020a - The Association of Gut Microbiota With Idiopathic Central Precocious Puberty in Girls
  • ElMouzan2018 - Microbiota profile in new-onset pediatric Crohn's disease: data from a non-Western population
  • Hayden2020 - Fecal dysbiosis in infants with cystic fibrosis is associated with early linear growth failure
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Kim2020a - Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension
  • Li2019c - Gut Microbiota Differs Between Parkinson's Disease Patients and Healthy Controls in Northeast China
  • Maji2018 - Gut microbiome contributes to impairment of immunity in pulmonary tuberculosis patients by alteration of butyrate and propionate producers
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • Sjodin2019 - Temporal and long-term gut microbiota variation in allergic disease: A prospective study from infancy to school age
  • Takahashi2016 - Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease
  • VillanuevaMillan2019 - Characterization of gut microbiota composition in HIV-infected patients with metabolic syndrome
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ROSEBURIA INULINIVORANS
  • Browne2016 - Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Karlsson2013 - Gut metagenome in European women with normal, impaired and diabetic glucose control
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • LeChatelier2013 - Richness of human gut microbiome correlates with metabolic markers
  • McLaughlin2010 - The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • PerisBondia2011 - The active human gut microbiota differs from the total microbiota.
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Walker2011 - High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease.
  • Wang2018 - A metagenome-wide association study of gut microbiota in asthma in UK adults
  • Wang2018a - Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR ROSEBURIA INULINIVORANS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: February 08, 2021