Ruminococcus bicirculans

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Ruminococcus bicirculans is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, coccus bacterium. It has been detected in at least 10 gut microbiome compilation studies or metastudies. The DNA G+C content is 42-43%. Ruminococcus bicirculans is a common gut coloniser. (Wegmann2013)



  • This organism has been recovered from human faeces. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • QUIRKS
  • In 94% of Europeans (unseenbio.com).
    • GENERAL CHARACTERISTICS (Wegmann2013);
    Character Response
  • ⥅
  • Substrates assimilated or utilised:
  • pyruvate;
    • SPECIAL FEATURES (Wegmann2013);
    Character Response
  • ✓
  • Metabolites produced:
  • formate; acetate; ethanolMajor;
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Quinolines:
  • ciprofloxacin;
  • NOTES

    This is a recently discovered and common species found in the human gut.

    Fuel sources used:
    It can use fibre and simple sugars for energy.

    Metabolites produced:
    Our genomic analysis indicates that most members of this species can produce the following metabolites: acetate, ammonia, BCAAs, lactate, biotin.

    Metabolites consumed:
    In addition, our genomic analysis indicates that most members of this species do not consume any reported metabolites.

  • References: [1]

  • Analysis of the carbohydrate active enzyme complement suggests an ability to utilize certain hemicelluloses, especially __glucans and xyloglucan, for growth that was confirmed experimentally. The enzymatic machinery enabling the degradation of cellulose and xylan by related cellulolytic ruminococci is however lacking in this species. While the genome indicated the capacity to synthesize purines, pyrimidines and all 20 amino acids, only genes for the synthesis of nicotinate, NAD+, NADP+ and coenzyme A were detected among the essential vitamins and co_factors, resulting in multiple growth requirements. [PMID: 23919528]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    One important member of both ruminant and human microbial communities is the bacterial genus Ruminococcus. Ruminococcus species are defined as strictly anaerobic, Gram-positive, non-motile cocci that do not produce endospores and require fermentable carbohydrates for growth. Evidence shows that Ruminococcus species are predominantly associated with herbivores and omnivores, relative to carnivores, and that significantly abundant Ruminococcus populations are absent in non-host-associated environments. [PMID: 28348838]

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Oscillospiraceae Genus:  Ruminococcus Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccus
    Health:  Unknown
    Source:  human faeces
    DNA G+C(%):  42-43
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Cellulose:  neg Inulin:  neg Pectin:  neg Starch:  neg Pyruvate:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ciprofloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)

    References

    SPECIFIC REFERENCES FOR RUMINOCOCCUS BICIRCULANS
  • Wegmann2013 - Complete genome of a new Firmicutes species belonging to the dominant human colonic microbiota ('Ruminococcus bicirculans') reveals two chromosomes and a selective capacity to utilize plant glucans.
  • Li2019c - Gut Microbiota Differs Between Parkinson's Disease Patients and Healthy Controls in Northeast China
  • Zeng2019 - Structural and functional profiles of the gut microbial community in polycystic ovary syndrome with insulin resistance (IR-PCOS): a pilot study
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR RUMINOCOCCUS BICIRCULANS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chung2019 - Impact of carbohydrate substrate complexity on the diversity of the human colonic microbiota.
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Urban2020 - Altered Fecal Microbiome Years after Traumatic Brain Injury
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • ...............................
    • GENERAL REFERENCES FOR RUMINOCOCCUS BICIRCULANS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: February 08, 2021