Ruminococcus champanellensis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Ruminococcus champanellensis is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, coccus bacterium. It has been detected in at least 13 gut microbiome compilation studies or metastudies. The DNA G+C content is 53.1%. Ruminococcus champanellensis is a common gut coloniser. (Chassard2012; Togo2018)



  • This organism has been recovered from human faeces. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal. Robust growth can have positive consequences for gut health.
    • QUIRKS
  • In 72% of Europeans (unseenbio.com).
    • GENERAL CHARACTERISTICS (Chassard2012); (Togo2018);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; cellulose;
  • pH
  • Acidity tolerance:
  • tolerates pH 6.5-6.8; Grows optimally at pH 6.8.
  • 🌡
  • Temperature tolerance:
  • grows at 33-39℃; Grows optimally at 39℃.
  • H+
  • Acid from carbohydrates usually produced:
  • cellulose; xylan; cellubiose;
  • ⥅
  • Substrates assimilated or utilised:
  • cellubiose; cellulose; xylan;
  • Active enzymes:
  • alkaline phosphatase; esterase C4; esterase lipase C8; α-galactosidase; β-galactosidase; β-glucosidase; naphthol-ASBI-P;
    • SPECIAL FEATURES (Chassard2012); (Togo2018);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; butyrate; succinate;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Quinolines:
  • ciprofloxacin;

  • N/A

  • R.champanellensis is able to degrade microcrystalline cellulose but the utilization of soluble sugars is restricted to cellobiose. Acetate and succinate are the major end products of cellulose and cellobiose fermentation. [PMID: 21357460). [UP000007054]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Ruminococcus champanellensis (strain DSM 18848 / JCM 17042 / 18P13) is a strictly anaerobic, cellulolytic, non-motile cocci, Gram-positive bacterium isolated from a human faecal sample. R.champanellensis is able to degrade microcrystalline cellulose but the utilization of soluble sugars is restricted to cellobiose. Acetate and succinate are the major end products of cellulose and cellobiose fermentation. (Adapted from PMID: 21357460). [UP000007054]

  • Chassard, C., Delmas, E., Robert, C., Lawson, P. A., & Bernalier-Donadille, A. (2012). Ruminococcus champanellensis sp. nov., a cellulose-degrading bacterium from human gut microbiota. International Journal of Systematic and Evolutionary Microbiology, 62(Pt 1), 138–143.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Oscillospiraceae Genus:  Ruminococcus Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccus
    Health:   Positive
    Source:  human faeces
    DNA G+C(%):  53.1
    Opt. T:  39℃
    Mid T(℃):  33-39(+)
    Opt. pH:  6.8
    pH 6.0-8.0:  6.5-6.8(+)
    		Aesculin:  + Urea:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Mannose:  neg D-Lyxose:  neg Rhamnose:  neg Sorbose:  neg Cellubiose:  + Cellulose:  + Starch:  neg Pectin:  neg Xylan:  + Adonitol:  neg D-Arabitol:  neg Dulcitol:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  neg Fructose:  neg Fucose:  neg Galactose:  neg Glucose:  neg D-Lyxose:  neg Mannose:  neg Rhamnose:  neg Ribose:  neg Sorbose:  neg D-Tagatose:  neg Xylose:  neg Cellubiose:  + Gentiobiose:  neg Lactose:  neg Maltose:  neg Melibiose:  neg Raffinose:  neg Sucrose:  neg D-Turanose:  neg Trehalose:  neg N_Acetyl_glucosamine:  neg Adonitol:  neg Amygdalin:  neg D-Arabitol:  neg Cellulose:  + Dulcitol:  neg Erythritol:  neg Glycerol:  neg Glycogen:  neg Inositol:  neg Inulin:  neg Mannitol:  neg Pectin:  neg Salicin:  neg Sorbitol:  neg Starch:  neg Xylan:  + Xylitol:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  + β-Galactosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  neg Chymotrypsin:  neg GluDC:  neg Trypsin:  neg AlanineAA:  neg CystineAA:  neg GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg ValAA:  neg AlkalineP:  + AcidP:  neg Esterase(C4):  + EstLip(C8):  + Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Butyrate:  + Succinate:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ciprofloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)

    References

    SPECIFIC REFERENCES FOR RUMINOCOCCUS CHAMPANELLENSIS
  • Chassard2012 - Ruminococcus champanellensis sp. nov., a cellulose-degrading bacterium from human gut microbiota.
  • Togo2018 - Description of Mediterraneibacter massiliensis, gen. nov., sp. nov., a new genus isolated from the gut microbiota of an obese patient and reclassification of Ruminococcus faecis, Ruminococcus lactaris, Ruminococcus torques, Ruminococcus gnavus and Clostridium glycyrrhizinilyticum as Mediterraneibacter faecis comb. nov., Mediterraneibacter lactaris comb. nov., Mediterraneibacter torques comb. nov., Mediterraneibacter gnavus comb. nov. and Mediterraneibacter glycyrrhizinilyticus comb. nov.
  • Bojovic2020 - Gut Microbiota Dysbiosis Associated With Altered Production of Short Chain Fatty Acids in Children With Neurodevelopmental Disorders
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR RUMINOCOCCUS CHAMPANELLENSIS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • LeChatelier2013 - Richness of human gut microbiome correlates with metabolic markers
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Wang2018 - A metagenome-wide association study of gut microbiota in asthma in UK adults
  • Wang2018a - Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR RUMINOCOCCUS CHAMPANELLENSIS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: February 08, 2021