Schaalia radingae

(aka Actinomyces radingae)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Schaalia radingae, (aka Actinomyces radingae), is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 3 gut microbiome compilation studies or metastudies. The DNA G+C content is 60%. Schaalia radingae is probably a rare gut coloniser. (Wuest1995)



  • This organism has been recovered from clinical sources (abscess, wound, blood - CCUG) and human faeces. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Wuest1995);
    Character Response
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; mannose; ribose; xylose; maltose; sucrose;
  • Active enzymes:
  • esterase C4; esterase lipase C8; Leu arylamidase;
    • SPECIAL FEATURES (Wuest1995);
    Character Response
  • ✓
  • Metabolites produced:
  • lactate; succinate;
  • Haemolysis:
  • weak, but usually absent
  • ±
  • Nitrate:
  • strain dependent
  • ✗
  • NO3➔NO2:
  • not reduced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; penicillin G;
  • Cephalosporins:
  • cefalexin;
  • Quinolines:
  • ciprofloxacin;
  • Heterocycles:
  • metronidazole;

  • Actinomyces radingae may be an opportunistic pathogen.

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Actinomycetales Family:  Actinomycetaceae Genus:  Schaalia Alt. name:  Actinomyces radingae Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  clinical sources (abscess, wound, blood - CCUG) and human faeces
    DNA G+C(%):  60
    		Aesculin:  neg Urea:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  vr Fructose:  vr Galactose:  vr Glucose:  + Mannose:  + Rhamnose:  neg Ribose:  + Xylose:  + Cellubiose:  vr Lactose:  vr Maltose:  + Melezitose:  vr Melibiose:  vr Sucrose:  + Trehalose:  vr Amygdalin:  neg Erythritol:  vr Inositol:  vr Mannitol:  neg Sorbitol:  neg Salicin:  vr
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Mannosidase:  neg Chymotrypsin:  neg Trypsin:  neg CystineAA:  neg LeuAA:  + PyrrolidAA:  neg AlkalineP:  neg Esterase(C4):  + EstLip(C8):  + Lipase:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(MIC50): 0.06, MIC90: 0.25, RNG: (≤0.015-0.5)
    penicillin_G:  S(MIC50): 0.06, MIC90: 0.25, RNG: (≤0.03-0.25)
    cefalexin:  S(MIC50): 0.25, MIC90: 1, RNG: (0.06-2)
    azithromycin:  Var(MIC50): 0.06, MIC90: >32, RNG: (≤0.03->32)
    erythromycin:  Var(MIC50): ≤0.03, MIC90: >32, RNG: (≤0.03->32)
    ciprofloxacin:  R(MIC50): 8, MIC90: >8, RNG: (≤0.5->8)
    levofloxacin:  Var(MIC50): 4, MIC90: 8, RNG: (≤0.06-8)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  Var(MIC50): 0.5, MIC90: 16, RNG: (0.125-16)
    metronidazole:  R(MIC50): 8, MIC90: >32, RNG: (≤0.03->32)
    clindamycin:  Var(MIC50): 0.125, MIC90: >32, RNG: (≤0.03->32)

    References

    SPECIFIC REFERENCES FOR SCHAALIA RADINGAE
  • Wuest1995 - Assignment of Actinomyces pyogenes-like (CDC coryneform group E) bacteria to the genus Actinomyces as Actinomyces radingae sp. nov. and Actinomyces turicensis sp. nov.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR SCHAALIA RADINGAE
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
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    • Added: April 08, 2021