Sneathia sanguinegens

(aka Leptotrichia sanguinegens)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Sneathia sanguinegens, (aka Leptotrichia sanguinegens), is a Gram-negative, non-spore-forming, anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 3 gut microbiome compilation studies or metastudies. The DNA G+C content is 22-25%. Sneathia sanguinegens is probably a rare gut coloniser. (Collins2001; Hanff1995)



  • This organism has been recovered from human faeces and clinical sources (amniotic fluid, blood, abdomen - CCUG). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: opportunistic in immunocompromised patients). It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Collins2001); (Hanff1995);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; hippurate;
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 35-37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; glucose; mannose; cellubiose; salicin;
  • ±
  • Strain-dependent acid from carbs:
  • raffinose;
  • Active enzymes:
  • alkaline phosphatase; acid phosphatase; Arg arylamidase; β-glucuronidase; phosphoamidase;
  • ±
  • Strain-dependent active enzymes:
  • esterase C4; esterase lipase C8; Glu-Glu arylamidase; Gly arylamidase; His arylamidase; Leu arylamidase; Phe arylamidase; Ser arylamidase; Tyr arylamidase;
    • SPECIAL FEATURES (Collins2001); (Hanff1995);
    Character Response
  • ✓
  • Metabolites produced:
  • formate (major); acetate (minor); lactate (major);
  • ✗
  • Metabolites not produced:
  • succinate; indole;
  • ✗
  • VP test:
  • not active
  • Haemolysis:
  • beta
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • NO3➔NO2:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Hanff1995);
    Class Active Resistant
  • Penicillins:
  • ampicillin;
  • Aminoglycosides:
  • gentamicin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Fusobacteria Class:  Fusobacteriia Order:  Fusobacteriales Family:  Leptotrichiaceae Genus:  Sneathia Alt. name:  Leptotrichia sanguinegens Gram stain:  neg O2 Relation.:  anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces and clinical sources (amniotic fluid, blood, abdomen - CCUG)
    DNA G+C(%):  22-25
    Opt. T:  35-37℃
    		Aesculin:  + Urea:  neg Starch:  neg Hippurate:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg L-Arabinose:  neg Fructose:  + Glucose:  + Mannose:  + Rhamnose:  neg Ribose:  neg D-Tagatose:  neg Xylose:  neg Cellubiose:  + Lactose:  neg Maltose:  neg Melezitose:  neg Melibiose:  neg Sucrose:  neg Trehalose:  neg Amygdalin:  neg Aesculin:  neg Glycogen:  neg Pectin:  neg D-Arabitol:  neg Erythritol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Me-α-D-Glc:  neg Salicin:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg α-Arab:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  + α-Mannosidase:  neg β-Mannosidase:  neg ArgDH:  neg Chymotrypsin:  neg GluDC:  neg Trypsin:  neg AlanineAA:  neg ArgAA:  + CystineAA:  neg GluGluAA:  d GlyTrpAA:  neg GlyAA:  d HisAA:  d LeuAA:  d LeuGlyAA:  neg ProAA:  neg PheAA:  d PyrogluAA:  neg SerAA:  d TyrAA:  d ValAA:  neg AlkalineP:  + AcidP:  + Esterase(C4):  d EstLip(C8):  d Lipase(C14):  neg Phosphoamidase:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Formate:  Major(+) Acetate:  minor(+) Lactate:  Major(+) Succinate:  neg Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ampicillin:  Sens
    gentamicin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)

    References

    SPECIFIC REFERENCES FOR SNEATHIA SANGUINEGENS
  • Collins2001 - Characterization of some strains from human clinical sources which resemble "Leptotrichia sanguinegens": description of Sneathia sanguinegens sp. nov., gen. nov.
  • Hanff1995 - Leptotrichia sanguinegens sp. nov., a new agent of postpartum and neonatal bacteremia.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR SNEATHIA SANGUINEGENS
  • Aujoulat2014 - Temporal dynamics of the very premature infant gut dominant microbiota.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • ...............................
    • Added: December 15, 2021