Streptococcus uberis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Streptococcus uberis is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, coccus bacterium. It has been detected in at least 5 gut microbiome compilation studies or metastudies. The DNA G+C content is 36-37.5%. Streptococcus uberis is probably a rare gut coloniser. (Whiley2011Bergey)



  • This organism has been recovered from human faeces, cows, and milk. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: human and animal pathogen). Is a known human pathogen. Likely to be transient and not a long-term gut commensal.
    • GENERAL CHARACTERISTICS (Whiley2011Bergey);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; arginine; hippurate;
  • 🧂
  • Salt tolerance:
  • tolerates 4% salt; tolerates 6.5% salt;
  • 💧
  • Bile tolerance:
  • Strain-variable at 40%
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 10℃; doesn't grow at 45℃;
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; galactose; glucose; mannose; ribose; D-tagatose; amygdalin; inulin; cellubiose; gentiobiose; lactose; maltose; sucrose; trehalose; mannitol; sorbitol; arbutin; α-methyl glucoside; β-methyl glucoside; N-Ac glucosamine; salicin;
  • ±
  • Strain-dependent acid from carbs:
  • glycogen;
  • ⥅
  • Substrates assimilated or utilised:
  • hippurate;
  • Active enzymes:
  • Ala arylamidase; Ala-Phe-Pro arylamidase; arginine dihydrolase; N-Ac β-glucosaminidase; α-glucosidase; β-glucosidase; β-glucuronidase; Gly arylamidase; hyaluridonase; Leu arylamidase; Leu-Gly arylamidase; leucine aminopeptidase; pyrrolidine arylamidase;
  • ±
  • Strain-dependent active enzymes:
  • alkaline phosphatase; pyroGlu arylamidase;
    • SPECIAL FEATURES (Whiley2011Bergey);
    Character Response
  • ✓
  • Metabolites produced:
  • lactate;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✓
  • VP test:
  • active
  • Haemolysis:
  • alpha
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Macrolides:
  • quinupristin-dalfopristin;
  • Tetracyclines:
  • tigecycline;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • linezolid;

  • Streptococci are members of the normal flora. Virulence factors of group A streptococci include (1) M protein and lipoteichoic acid for attachment; (2) a hyaluronic acid capsule that inhibits phagocytosis; (3) other extracellular products, such as pyrogenic (erythrogenic) toxin, which causes the rash of scarlet fever; and (4) streptokinase, streptodornase (DNase B), and streptolysins. Some strains are nephritogenic. Immune-mediated sequelae do not reflect dissemination of bacteria. Nongroup A strains have no defined virulence factors. In humans, diseases associated with the streptococci occur chiefly in the respiratory tract, bloodstream, or as skin infections. [https://www.ncbi.nlm.nih.gov/books/NBK7611/]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    The genus Streptococcus , a heterogeneous group of Gram-positive bacteria, has broad significance in medicine and industry. Various streptococci are important ecologically as part of the normal microbial flora of animals and humans; some can also cause diseases that range from subacute to acute or even chronic. Among the significant human diseases attributable to streptococci are scarlet fever, rheumatic heart disease, glomerulonephritis, and pneumococcal pneumonia. Streptococci are essential in industrial and dairy processes and as indicators of pollution. [https://www.ncbi.nlm.nih.gov/books/NBK7611/]

  • Finegold, S. M., Howard, R. A., & Vera, L. S. (1974). Effect of diet on human intestinal fecal flora: comparison of Japanese and American diets. Am. J. Clin. Nutr, 27, 1456–1469.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Bacilli Order:  Lactobacillales Family:  Streptococcaceae Genus:  Streptococcus Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccus
    Health:  Unknown
    Source:  human faeces, cows, and milk
    DNA G+C(%):  36-37.5
    Low T(℃):  10(neg)
    High T(℃):  45(neg)
    NaCl 3-5%:  4(+)
    NaCl >6%:  6.5(+)
    Bile reaction(%):  40(d)
    		Aesculin:  + Urea:  neg Arginine:  + DNA:  neg Hippurate:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg D-Arabinose:  neg L-Arabinose:  neg Fructose:  + Fucose:  neg D-Fucose:  neg Galactose:  + Glucose:  + Mannose:  + Rhamnose:  neg Ribose:  + Sorbose:  neg D-Tagatose:  d(+) Xylose:  neg L-Xylose:  neg Cellubiose:  + Gentiobiose:  + Lactose:  + Maltose:  + Melezitose:  neg Melibiose:  neg Sucrose:  + Trehalose:  + Turanose:  neg Amygdalin:  + Dextrin:  neg Glycogen:  d(neg) Inulin:  + Starch:  vr Adonitol:  neg D-Arabitol:  neg L-Arabitol:  neg Dulcitol:  neg Erythritol:  neg Glycerol:  neg Inositol:  neg Mannitol:  + Sorbitol:  + Xylitol:  neg Arbutin:  + Gluconate:  neg 2-Ketogluconate:  neg 5-Ketogluconate:  neg Me-α-D-Glc:  d(+) Me-α-D-Mann:  neg Me-Xyloside:  neg NAc-α-GA:  + Salicin:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Melibiose:  neg Hippurate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Hyaluridonase:  + Ac-β-glcamnd:  + α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  + β-Mannosidase:  vr ArgDH:  + GluDC:  neg LeuAP:  + AlanineAA:  + AlaPheProAA:  + GluGluAA:  neg GlyAA:  + LeuAA:  + LeuGlyAA:  + PyrrolidAA:  + PyrogluAA:  d AlkalineP:  d DNAse:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Lactate:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin_G:  Var(MIC50): 0.25, MIC90: 8, RNG: (<0.015->16)
    quin-dalf:  S(MIC50): 0.5, MIC90: 1, RNG: (<0.06-2)
    linezolid:  S(MIC50): 1, MIC90: 1, RNG: (0.12-2)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  Var(MIC50): >2, MIC90: >8, RNG: (<2->8)
    tigecycline:  S(MIC50): 0.015, MIC90: 0.12, RNG: (<0.015-0.5)
    vancomycin:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25-2)

    References

    SPECIFIC REFERENCES FOR STREPTOCOCCUS UBERIS
  • Whiley2011Bergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Streptococcaceae, Genus I. Streptococcus
  • Cassir2015 - Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
  • Hynes2000 - Hyaluronidases of Gram-positive bacteria.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR STREPTOCOCCUS UBERIS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Cassir2015 - Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
  • Finegold1974 - Effect of diet on human fecal flora: comparison of Japanese and American diets
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • ...............................
    • GENERAL REFERENCES FOR STREPTOCOCCUS UBERIS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021