Tannerella forsythia

(aka Bacteroides forsythus)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Tannerella forsythia, (aka Bacteroides forsythus), is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 12 gut microbiome compilation studies or metastudies. The DNA G+C content is 46%. Tannerella forsythia is probably a common, although minor, coloniser of the gut. (Sakamoto2010Bergey; Tanner1986)



  • This organism has been recovered from human faeces, and oral cavity. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Sakamoto2010Bergey); (Tanner1986);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • 💧
  • Bile tolerance:
  • Doesn't tolerate 20% bile
  • pH
  • Acidity tolerance:
  • doesn't tolerate pH 4.5; tolerates pH 7.0; tolerates pH 8.5; Grows optimally at pH 7.5–8.0.
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 45℃;
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; galactose; glucose; mannose; D-tagatose; amygdalin; cellubiose; maltose; melezitose; sucrose; trehalose; dulcitol; mannitol; arbutin; gluconate;
  • Active enzymes:
  • Ala arylamidase; arabinosidase; Arg arylamidase; N-Ac β-glucosaminidase; fucosidase; α-galactosidase; β-galactosidase; β-glucosidase; β-glucuronidase; His arylamidase; Phe arylamidase; trypsin;
    • SPECIAL FEATURES (Sakamoto2010Bergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; propionate; butyrate; isobutyrate (minor); succinate (minor); isovalerate;
    • RESPONSE TO ANTIBIOTICS (AlmaguerFlores2006); (Sakamoto2010Bergey);
    Class Active Resistant
  • Penicillins:
  • amoxicillin;
  • Tetracyclines:
  • doxycycline;

  • N/A

  • T. forsythia is strongly associated with the pathogenesis and progression of periodontitis. To provide a better understanding of the contribution of T. forsythia to the onset of periodontal disease, we have focused our research efforts on the in vivo gene expression patterns of T. forsythia, during periodontitis progression. our studies revealed that T. forsythia expressed bfor_1659 at high levels during periodontitis progression and most importantly this up-regulation occurs within the periodontal pocket in which bacteria-bacteria and bacteria-host interactions shape its behavior, thus validating BFoR_1659 potential clinical relevance. BFo_1659 has high homology to DPP IV, at its N-terminal end and belongs to the serine protease family. At the functional level, DPP IV is an ectopeptidase associated with degradation of collage, cleaving X-Pro or X-Ala dipeptide at the penultimate position from N-terminal ends of polypeptide chains. [PMID: 30171738]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Tannerella forsythia is one of three pathogens most commonly associated with periodontitis, a group of diseases characterized by inflammation and damage to the supporting structures of the tooth, known collectively as the red complex. T.forsythia is a nutritionally fastidious periodontal pathogen in the laboratory, however it is able to substitute its requirement for N-acetylmuramic acid, a building block used to produce cell wall peptidoglycans, with sialic acid in biofilm culture. This suggests that in vivo it may actually be more adaptable than its fastidious laboratory growth requirements suggest. Strain ATCC 43037 is the type strain of the species and was isolated from the human periodontal pocket (adapted from PMID 22230462). [UP000005436]

  • Macfarlane, S., Furrie, E., Cummings, J. H., & Macfarlane, G. T. (2004). Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 38(12), 1690–1699.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Bacteroidia Order:  Bacteroidales Family:  Tannerellaceae Genus:  Tannerella Alt. name:  Bacteroides forsythus Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces, and oral cavity
    DNA G+C(%):  46
    High T(℃):  45(neg)
    Opt. pH:  7.5–8.0
    pH 4.2-5.9:  4.5(neg)
    pH 6.0-8.0:  7.0(+)
    pH >8:  8.5(+)
    Bile reaction(%):  20(neg)
    		Aesculin:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg L-Arabinose:  neg Fructose:  + Galactose:  + Glucose:  + Mannose:  + Rhamnose:  neg Ribose:  neg D-Tagatose:  + Cellubiose:  + Lactose:  neg Maltose:  + Melezitose:  + Sucrose:  + Trehalose:  + Amygdalin:  + Inulin:  neg Dulcitol:  + Glycerol:  neg Mannitol:  + Sorbitol:  neg Arbutin:  + Gluconate:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Melibiose:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    α-Arab:  + Ac-β-glcamnd:  + α-Fucosidase:  + α-Galactosidase:  + β-Galactosidase:  + β-Glucosidase:  + β-Glucuronidase:  + Trypsin:  + AlanineAA:  + ArgAA:  + HisAA:  + PheAA:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  S(8)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(0.5)

    References

    SPECIFIC REFERENCES FOR TANNERELLA FORSYTHIA
  • AlmaguerFlores2006 - Proportion of antibiotic resistance in subgingival plaque samples from Mexican subjects.
  • Maiden2003 - Proposal to conserve the adjectival form of the specific epithet in the reclassification of Bacteroides forsythus Tanner et al. 1986 to the genus Tannerella Sakamoto et al. 2002 as Tannerella forsythia corrig., gen. nov., comb. nov. Request for an Opinion.
  • Sakamoto2010Bergey - Bergey's manual of systematic bacteriology: Vol. 4. The Bacteroidetes. Family III. Porphyromonoadaceae, Genus VII. Tannerella
  • Tanner1986 - Bacteroides forsythus sp. nov., a Slow-Growing, Fusiform Bacteroides sp. from the Human Oral Cavity.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR TANNERELLA FORSYTHIA
  • Bik2006 - Molecular analysis of the bacterial microbiota in the human stomach.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • De2020 - Metagenomic analysis of gut microbiome and resistome of diarrheal fecal samples from Kolkata, India, reveals the core and variable microbiota including signatures of microbial dark matter.
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • MacFarlane2004 - Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis.
  • McLaughlin2010 - The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Woodmansey2004 - Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
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    • Added: February 08, 2021