Thomasclavelia saccharogumia

(aka Clostridium saccharogumia)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Thomasclavelia saccharogumia, (aka Clostridium saccharogumia), is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, helical-shaped bacterium. It has been detected in at least 4 gut microbiome compilation studies or metastudies. The DNA G+C content is 29.4-31.7%. Thomasclavelia saccharogumia is probably a rare gut coloniser. (Clavel2007; Rainey2011jBergey)



  • This organism has been recovered from human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Clavel2007); (Rainey2011jBergey);
    Character Response
  • pH
  • Acidity tolerance:
  • tolerates pH 6; tolerates pH 9;
  • 🌡
  • Temperature tolerance:
  • grows at 25℃; grows at 45℃;
  • ⥅
  • Substrates assimilated or utilised:
  • cellubiose; fructose; galactose; glucose; lactose; mannose; salicin; sucrose;
  • Active enzymes:
  • α-galactosidase;
    • SPECIAL FEATURES (Clavel2007); (Rainey2011jBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate (minor); butyrate;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Haemolysis:
  • absent
    • RESPONSE TO ANTIBIOTICS (Clavel2007);
    Class Active Resistant
  • Penicillins:
  • penicillin G;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;

  • Clavel, T., Lippman, R., Gavini, F., Doré, J., & Blaut, M. (2007). Clostridium saccharogumia sp. nov. and Lactonifactor longoviformis gen. nov., sp. nov., two novel human faecal bacteria involved in the conversion of the dietary phytoestrogen secoisolariciresinol diglucoside. Systematic and Applied Microbiology, 30(1), 16–26.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Clostridiaceae Genus:  Thomasclavelia Alt. name:  Clostridium saccharogumia Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Helical
    Health:  Unknown
    Source:  human faeces
    DNA G+C(%):  29.4-31.7
    Lower T(℃):  25(+)
    High T(℃):  45(+)
    pH 6.0-8.0:  6(+)
    pH >8:  9(+)
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Fructose:  + Galactose:  + Glucose:  + Mannose:  + Rhamnose:  neg Cellubiose:  + Lactose:  + Maltose:  neg Melibiose:  neg Raffinose:  neg Sucrose:  + Trehalose:  neg Salicin:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg α-Galactosidase:  + α-Glucosidase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  minor(+) Butyrate:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin_G:  R(0.5)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  S(0.5)
    rifampicin:  R(15)
    metronidazole:  R(15)

    References

    SPECIFIC REFERENCES FOR THOMASCLAVELIA SACCHAROGUMIA
  • Clavel2007 - Clostridium saccharogumia sp. nov. and Lactonifactor longoviformis gen. nov., sp. nov., two novel human faecal bacteria involved in the conversion of the dietary phytoestrogen secoisolariciresinol diglucoside.
  • Rainey2011jBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Clostridiaceae, Genus I. Clostridium - Cluster XVIII
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR THOMASCLAVELIA SACCHAROGUMIA
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • PerezBrocal2015 - Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • ...............................
    • GENERAL REFERENCES FOR THOMASCLAVELIA SACCHAROGUMIA
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
  • Alkhalil2017 - Bacterial involvements in ulcerative colitis: molecular and microbiological studies
    • Added: April 08, 2021