Tissierella praeacuta

(aka Bacteroides praeacutus)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Tissierella praeacuta, (aka Bacteroides praeacutus), is a Gram-positive, non-spore-forming, strictly anaerobic, motile, rod-shaped bacterium. It has been detected in at least 5 gut microbiome compilation studies or metastudies. The DNA G+C content is 28%. Tissierella praeacuta is probably a rare gut coloniser. (Collins1986a; Shah2011Bergey)



  • This organism has been recovered from human faeces, and clinical sources (gangrenous lesions, abscesses and blood). The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: human and animal pathogen). It is an opportunistic pathogen. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Collins1986a); (Shah2011Bergey);
    Character Response
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • glucose;
  • Active enzymes:
  • naphthol-ASBI-P;
    • SPECIAL FEATURES (Collins1986a); (Shah2011Bergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; butyrate; isovalerate; H₂S;
  • ✗
  • Metabolites not produced:
  • indole;
  • Nitrate:
  • reduction is variable
    • RESPONSE TO ANTIBIOTICS (Citron2012); (Goldstein2006); (Citron2001); (Goldstein2000a); (Citron1997);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; ampicillin-sulbactam; imipenem; penicillin; ticarcillin-clavulanic acid;
  • Cephalosporins:
  • cefoperazone; ceftizoxime;
  • Macrolides:
  • azithromycin; clarithromycin; erythromycin; roxithromycin;
  • Quinolines:
  • trovafloxacin;
  • Heterocycles:
  • chloramphenicol; metronidazole;
  • Vancomycins:
  • vancomycin;

  • Tissier, MH (1900). Recherches sur la flore intestinale normale et pathologique du nourrisson. Medicine Paris.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Tissierellia Order:  Tissierellales Family:  Tissierellaceae Genus:  Tissierella Alt. name:  Bacteroides praeacutus Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Swimming Morphology:  Rod
    Health:  Unknown
    Source:  human faeces, and clinical sources (gangrenous lesions, abscesses and blood)
    DNA G+C(%):  28
    Opt. T:  37℃
    		Aesculin:  neg Urea:  neg Gelatin:  vr Hippurate:  vr
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Butyrate:  + Isovalerate:  + H2S:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(MIC50): 0.5, MIC90: 0.5, RNG: (0.5)
    amp-sulb:  S(MIC50): 0.125, MIC90: 1, RNG: (0.06–2)
    penicillin:  S(MIC50): 0.25, MIC90: 2, RNG: (0.06–2)
    piper-taz:  Var(MIC50): 0.25, MIC90: >128, RNG: (0.06->128)
    tica-clav:  S(MIC50): 0.25, MIC90: 4, RNG: (0.06->128)
    imipenem:  S(MIC50): 0.125, MIC90: 0.5, RNG: (0.015–16)
    cefoperazone:  S(0.25)
    cefotetan:  Var(MIC50): 1, MIC90: 32, RNG: (0.25–128)
    cefoxitin:  Var(MIC50): 2, MIC90: 32, RNG: (0.25–>128)
    ceftizoxime:  S(0.125)
    azithromycin:  R(MIC50): >32, MIC90: >32, RNG: (0.5–>32)
    erythromycin:  R(MIC50): >32, MIC90: >32, RNG: (1–>32)
    clarithromycin:  R(MIC50): 32, MIC90: >32, RNG: (0.25–>32)
    roxithromycin:  R(MIC50): >32, MIC90: >32, RNG: (1–>32)
    telithromycin:  Var(MIC50): 1, MIC90: >32, RNG: (0.06–>32)
    ciprofloxacin:  Var(MIC50): 1, MIC90: 4, RNG: (0.5–8)
    levofloxacin:  Var(MIC50): 4, MIC90: 8, RNG: (0.15–16)
    moxifloxacin:  Var(MIC50): 1, MIC90: 4, RNG: (0.25–8)
    ofloxacin:  Var(MIC50): 2, MIC90: 4, RNG: (1–16)
    trovafloxacin:  S(MIC50): 0.06, MIC90: 0.125, RNG: (0.015–0.125)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  S(MIC50): 1, MIC90: 2, RNG: (0.25–32)
    chloramphenicol:  S(MIC50): 2, MIC90: 8, RNG: (0.25–32)
    metronidazole:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–8)
    clindamycin:  Var(MIC50): 4, MIC90: 8, RNG: (0.125–>32)

    References

    SPECIFIC REFERENCES FOR TISSIERELLA PRAEACUTA
  • Bae2004 - Clostridium hastiforme is a later synonym of Tissierella praeacuta.
  • Collins1986a - Notes: Reclassification of Bacteroides praeacutus Tissier (Holdeman and Moore) in a New Genus, Tissierella, as Tissierella praeacuta comb. nov.
  • Shah2011Bergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Clostridiales, Family XI. Incertae Sedis, Genus X. Tissierella
  • Citron2012 - In vitro activities of CB-183,315, vancomycin, and metronidazole against 556 strains of Clostridium difficile, 445 other intestinal anaerobes, and 56 Enterobacteriaceae species.
  • Goldstein2006 - In vitro activity of moxifloxacin against 923 anaerobes isolated from human intra-abdominal infections.
  • Citron2001 - Comparative in vitro activities of ABT-773 against 362 clinical isolates of anaerobic bacteria.
  • Goldstein2000a - Comparative In vitro activities of ertapenem (MK-0826) against 1,001 anaerobes isolated from human intra-abdominal infections.
  • Citron1997 - Comparative in vitro activities of trovafloxacin (CP-99,219) against 221 aerobic and 217 anaerobic bacteria isolated from patients with intra-abdominal infections.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR TISSIERELLA PRAEACUTA
  • Benno1984 - The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Walker2011 - High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease.
  • ...............................
    • GENERAL REFERENCES FOR TISSIERELLA PRAEACUTA
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021