Treponema denticola

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Treponema denticola is a Gram-negative, non-spore-forming, anaerobic, motile, spirochete bacterium. It has been detected in at least 3 gut microbiome compilation studies or metastudies. The DNA G+C content is 37-39%. Treponema denticola is probably a rare gut coloniser. (Norris2010Bergey)



  • This organism has been recovered from oral cavities between teeth and gums. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: human and animal pathogen). Could be a possible pathogen in humans, but unknown at this stage. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Norris2010Bergey);
    Character Response
  • pH
  • Acidity tolerance:
  • tolerates pH 6.5-8.0;
  • 🌡
  • Temperature tolerance:
  • grows at 30℃; grows at 42℃;
  • ⥅
  • Substrates assimilated or utilised:
  • alanine; arginine; cysteine; glycine; ornithine; serine;
    • SPECIAL FEATURES (Norris2010Bergey);
    Character Response
  • ✓
  • Metabolites produced:
  • formate (minor); acetate; lactate (minor); succinate (minor); ammonia;
  • ✗
  • Methyl red test:
  • not active
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Penicillins:
  • penicillin G;
  • Macrolides:
  • spiramycin;
  • Tetracyclines:
  • tetracycline;
  • Aminoglycosides:
  • streptomycin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • metronidazole;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Spirochaetes Class:  Spirochaetia Order:  Spirochaetales Family:  Treponemataceae Genus:  Treponema Gram stain:  neg O2 Relation.:  anaerobic Spore:  No spore Motility:  Swimming Morphology:  Spirochete
    Health:  Unknown
    Source:  oral cavities between teeth and gums
    DNA G+C(%):  37-39
    Lower T(℃):  30(+)
    High T(℃):  42(+)
    pH 6.0-8.0:  6.5-8.0(+)
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Ala:  + Arg:  + Cys:  + Gly:  + Orn:  + Ser:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin_G:  Sens
    streptomycin:  Sens
    spiramycin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  Sens
    rifampicin:  R(50)
    metronidazole:  Sens

    References

    SPECIFIC REFERENCES FOR TREPONEMA DENTICOLA
  • Norris2010Bergey - Bergey's manual of systematic bacteriology. Vol. 4, The Spirochetes. Family Spirochaetaceae, Genus IV. Treponema
  • Chan1993 - Treponema denticola (ex Brumpt 1925) sp. nov., nom. rev., and identification of new spirochete isolates from periodontal pockets.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR TREPONEMA DENTICOLA
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
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    • Added: October 05, 2022