Treponema succinifaciens

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Treponema succinifaciens is a Gram-negative, non-spore-forming, strictly anaerobic, motile, spirochete bacterium. It has been detected in at least 5 gut microbiome compilation studies or metastudies. The DNA G+C content is 36%. Treponema succinifaciens is probably a rare gut coloniser. (Cwyk1979; Norris2010Bergey)



  • This organism has been recovered from human faeces and pig intestine. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Cwyk1979); (Norris2010Bergey);
    Character Response
  • 🧂
  • Salt tolerance:
  • doesn't tolerate 6.5% salt;
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 22℃; grows at 37℃; doesn't grow at 43℃; Grows optimally at 35-39℃.
  • H+
  • Acid from carbohydrates usually produced:
  • L-arabinose; galactose; glucose; mannose; xylose; starch; cellubiose; lactose; maltose;
  • ⥅
  • Substrates assimilated or utilised:
  • L-arabinose; cellubiose; dextrin; galactose; glucose; lactose; maltose; mannose; starch; xylose;
    • SPECIAL FEATURES (Cwyk1979); (Norris2010Bergey);
    Character Response
  • ✓
  • Metabolites produced:
  • formate; acetate; lactate; succinate; pyruvate (minor);
    • RESPONSE TO ANTIBIOTICS (Cwyk1979);
    Class Active Resistant
  • Penicillins:
  • penicillin G;
  • Cephalosporins:
  • cephalothin;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • oxytetracycline; tetracycline;
  • Aminoglycosides:
  • streptomycin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • chloramphenicol;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • polymyxin B;
  • NOTES

    Utilises N-acetylgalactosamine.  This seems rare among gut bacteria (Bergy's manual).

  • T. succinifaciens requires CO2 for growth and is able to utilize arabinose, xylose, glucose, mannose, galactose, maltose, lactose, cellobiose, dextrin and starch for fermentation. Sugar alcohols, amino acids and other organic acids cannot be fermented by the organism. Major fermentation products of glucose are acetate, formate, succinate and lactate, whereas pyruvate, acetoin and 2,3-butanediol are formed in minor amounts. Assays of enzymatic activities showed that T. succinifaciens dissimilates glucose via the Embden-Meyerhof pathway. The species caintains succinic acid-producing properties. [PMID: 21886863]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Strain 6091T (= DSM 2489 = ATCC 33096 = JCM 13475) is the type strain of Treponema succinifaciens. The species has succinic acid-producing properties. The strain is a harmless inhabitant of the intestine of healthy pigs and has previously shown to have no pathogenic potential. [PMID: 21886863] Treponema succinifaciens is a non-pathogenic, obligately anaerobic spirochete isolated from the colon of a swine (adapted from PMID 120726). [UP000006852]

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Spirochaetes Class:  Spirochaetia Order:  Spirochaetales Family:  Treponemataceae Genus:  Treponema Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Swimming Morphology:  Spirochete
    Health:  Unknown
    Source:  human faeces and pig intestine
    DNA G+C(%):  36
    Opt. T:  35-39℃
    Lower T(℃):  22(neg)
    Mid T(℃):  37(+)
    High T(℃):  43(neg)
    NaCl >6%:  6.5(neg)
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  + Galactose:  + Glucose:  + Mannose:  + Ribose:  neg Sorbose:  neg Xylose:  + Cellubiose:  + Lactose:  + Maltose:  + Cellulose:  neg Inulin:  neg Starch:  + Dulcitol:  neg Glycerol:  neg Sorbitol:  neg Xylitol:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    L-Arabinose:  + Fructose:  neg Galactose:  + Glucose:  + Mannose:  + Rhamnose:  neg Ribose:  neg Sorbose:  neg Xylose:  + Cellubiose:  + Lactose:  + Maltose:  + Raffinose:  neg Sucrose:  neg Trehalose:  neg Cellulose:  neg Dextrin:  + Dulcitol:  neg Gluconate:  neg Glycerol:  neg Inulin:  neg Mannitol:  neg Sorbitol:  neg Starch:  + Xylitol:  neg Acetate:  neg Formate:  neg Lactate:  neg Pyruvate:  neg Succinate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin_G:  S(4U)
    cephalothin:  S(4; disc)
    streptomycin:  R(4; disc)
    erythromycin:  R(4; disc)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    oxytetracycline:  R(4; disc)
    tetracycline:  R(4; disc)
    vancomycin:  R(4; disc)
    rifampicin:  R(4; disc)
    chloramphenicol:  S(4; disc)
    polymyxin_B:  R(40U)

    References

    SPECIFIC REFERENCES FOR TREPONEMA SUCCINIFACIENS
  • Cwyk1979 - Treponema succinifaciens sp. nov., an anaerobic spirochete from the swine intestine.
  • Norris2010Bergey - Bergey's manual of systematic bacteriology. Vol. 4, The Spirochetes. Family Spirochaetaceae, Genus IV. Treponema
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR TREPONEMA SUCCINIFACIENS
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
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    • Added: February 08, 2021