Weissella cibaria

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Weissella cibaria is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 9 gut microbiome compilation studies or metastudies. The DNA G+C content is 44-45%. Weissella cibaria is probably a common, although minor, coloniser of the gut. (Bjoerkroth2002; Bjorkroth2011Bergey)



  • This organism has been recovered from human faeces, fermented food, and clinical specimens (gall, urine - CCUG). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: human and animal pathogen; opportunistic in immunocompromised patients). Is a known human pathogen. Is a known gut commensal.
    • QUIRKS
  • Found in human breast milk (Jeurink2013).
    • GENERAL CHARACTERISTICS (Bjoerkroth2002); (Bjorkroth2011Bergey);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; arginine;
  • 🧂
  • Salt tolerance:
  • tolerates 6.5% salt;
  • 🌡
  • Temperature tolerance:
  • grows at 15℃; grows at 45℃;
  • H+
  • Acid from carbohydrates usually produced:
  • L-arabinose; fructose; glucose; mannose; xylose; amygdalin; aesculin; cellubiose; gentiobiose; maltose; sucrose; arbutin; N-Ac glucosamine; salicin;
  • Active enzymes:
  • Ala-Phe-Pro arylamidase; β-galactosidase; β-glucosidase;
    • SPECIAL FEATURES (Bjoerkroth2002); (Bjorkroth2011Bergey);
    Character Response
  • ✓
  • Metabolites produced:
  • lactate;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✓
  • VP test:
  • active
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Citron2012a);
    Class Active Resistant
  • Penicillins:
  • ampicillin; ampicillin-sulbactam; imipenem; piperacillin-tazobactam;
  • Cephalosporins:
  • cefoxitin;
  • Macrolides:
  • fidaxomicin;
  • Quinolines:
  • moxifloxacin;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin;

  • Björkroth, K. J., Schillinger, U., Geisen, R., Weiss, N., Hoste, B., Holzapfel, W. H., Korkeala, H. J., & Vandamme, P. (2002). Taxonomic study of Weissella confusa and description of Weissella cibaria sp. nov., detected in food and clinical samples. International Journal of Systematic and Evolutionary Microbiology, 52(Pt 1), 141–148.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Bacilli Order:  Lactobacillales Family:  Leuconostocaceae Genus:  Weissella Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces, fermented food, and clinical specimens (gall, urine - CCUG)
    DNA G+C(%):  44-45
    Low T(℃):  15(+)
    High T(℃):  45(+)
    NaCl >6%:  6.5(+)
    		Aesculin:  + Urea:  neg Arginine:  + Hippurate:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    D-Arabinose:  neg L-Arabinose:  + Fructose:  + Fucose:  neg D-Fucose:  neg Galactose:  neg Glucose:  + Mannose:  + D-Lyxose:  neg Rhamnose:  neg Ribose:  neg Sorbose:  neg D-Tagatose:  neg Xylose:  + L-Xylose:  neg Cellubiose:  + Gentiobiose:  + Lactose:  neg Maltose:  + Melezitose:  neg Melibiose:  neg Sucrose:  + Trehalose:  neg Turanose:  neg Amygdalin:  + Dextrin:  neg Aesculin:  + Glycogen:  neg Inulin:  neg Starch:  neg Adonitol:  neg D-Arabitol:  neg L-Arabitol:  neg Dulcitol:  neg Erythritol:  neg Glycerol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Xylitol:  neg Arbutin:  + Gluconate:  neg 2-Ketogluconate:  neg 5-Ketogluconate:  neg Me-α-D-Glc:  neg Me-α-D-Mann:  neg Me-Xyloside:  neg NAc-α-GA:  + Salicin:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Melibiose:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  + α-Glucosidase:  vr β-Glucosidase:  + β-Glucuronidase:  neg β-Mannosidase:  vr GluDC:  neg AlanineAA:  neg AlaPheProAA:  + GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Lactate:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ampicillin:  S(MIC50): 0.25, MIC90: 1, RNG: (0.125–2)
    amp-sulb:  S(MIC50): 0.25, MIC90: 1, RNG: (0.125–2)
    piper-taz:  S(MIC50): 2, MIC90: 4, RNG: (2–8)
    imipenem:  S(MIC50): 0.25, MIC90: 4, RNG: (0.25–4)
    cefoxitin:  R(MIC50): >32, MIC90: >32, RNG: (>32)
    fidaxomicin:  R(MIC50): >32, MIC90: >32, RNG: (2–>32)
    moxifloxacin:  S(MIC50): 0.5, MIC90: 2, RNG: (0.25–2)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  R(MIC50): >16, MIC90: >16, RNG: (0.5–>16)
    clindamycin:  S(MIC50): 0.125, MIC90: 0.25, RNG: (0.125–0.25)

    References

    SPECIFIC REFERENCES FOR WEISSELLA CIBARIA
  • Bjoerkroth2002 - Taxonomic study of Weissella confusa and description of Weissella cibaria sp. nov., detected in food and clinical samples.
  • Bjorkroth2011Bergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Leuconostocaceae, Genus III. Weissella
  • Citron2012a - Comparative in vitro activities of LFF571 against Clostridium difficile and 630 other intestinal strains of aerobic and anaerobic bacteria.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR WEISSELLA CIBARIA
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR WEISSELLA CIBARIA
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
    • Added: April 08, 2021