Wolinella succinogenes

(aka Vibrio succinogenes)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Wolinella succinogenes, (aka Vibrio succinogenes), is a Gram-negative, non-spore-forming, anaerobic, motile, helical-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 46-49%. Wolinella succinogenes is probably a rare gut coloniser. (Tanner1981; Baar2003; Wolin1961)



  • This organism has been recovered from bovine rumen. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • QUIRKS
  • Hydrogen and formate are used as energy sources; carbohydrates are not fermented and don't support growth. Has acquired the genes necessary for N2 fixation, probably by lateral gene transfer from cyanobacteria.
    • GENERAL CHARACTERISTICS (Tanner1981); (Baar2003); (Wolin1961);
    Character Response
  • ⥅
  • Substrates assimilated or utilised:
  • formate; fumarate;
    • SPECIAL FEATURES (Tanner1981);
    Character Response
  • ✓
  • Metabolites produced:
  • succinate; H₂S; CO₂; H₂;
  • ✗
  • Metabolites not produced:
  • ammonia; indole;
  • ✗
  • VP test:
  • not active
  • ✓
  • Nitrate:
  • reduced
  • ✓
  • Nitrite:
  • reduced
    • RESPONSE TO ANTIBIOTICS (Tanner1981);
    Class Active Resistant
  • Penicillins:
  • penicillin;
  • Tetracyclines:
  • tetracycline;
  • Quinolines:
  • nalidixic-acid;
  • Aminoglycosides:
  • neomycin;
  • Polypep/ketides:
  • bacitracin; rifampicin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin; colistin; polymyxin B;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Epsilonproteobacteria Order:  Campylobacterales Family:  Helicobacteraceae Genus:  Wolinella Alt. name:  Vibrio succinogenes Gram stain:  neg O2 Relation.:  anaerobic Spore:  No spore Motility:  Swimming Morphology:  Helical
    Health:  Unknown
    Source:  bovine rumen
    DNA G+C(%):  46-49
    		Aesculin:  neg Urea:  neg Gelatin:  neg Starch:  neg Casein:  neg DNA:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Formate:  + Fumarate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg ArgDC:  neg LysDC:  neg OrnDC:  neg Lecithinase:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Succinate:  + H2S:  + Ammonia:  neg CO2:  + H2:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin:  R(8->128)
    gentamicin:  Var(MIC50): 2-8), MIC90: Var(2-8
    kanamycin:  Var(MIC50): 8), MIC90: Var(8
    neomycin:  R(16-32)
    streptomycin:  Var(MIC50): 2-8), MIC90: Var(2-8
    erythromycin:  Var(MIC50): 2-8), MIC90: Var(2-8
    nalidixic-acid:  R(32-128)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    minocycline:  Var(MIC50): 0.05-4), MIC90: Var(0.05-4
    tetracycline:  SensRNG: (0.5-2)
    vancomycin:  R(>128)
    bacitracin:  R(128)
    rifampicin:  R(128)
    chloramphenicol:  Var(MIC50): 2-8), MIC90: Var(2-8
    metronidazole:  SensRNG: (1-2)
    clindamycin:  SensRNG: (1-2)
    colistin:  SensRNG: (2-4)
    polymyxin_B:  SensRNG: (1-8)

    References

    SPECIFIC REFERENCES FOR WOLINELLA SUCCINOGENES
  • Tanner1981 - Wolinella gen. nov., Wolinella succinogenes (Vibrio succinogenes Wolin et al.) comb. nov., and Description of Bacteroides gracilis sp. nov., Wolinella recta sp. nov., Campylobacter concisus sp. nov., and Eikenella corrodens from Humans with Periodontal Disease.
  • Baar2003 - Complete genome sequence and analysis of Wolinella succinogenes. Proc Natl Acad Sci U S A.
  • Wolin1961 - Cytochrome-producing anaerobic Vibrio succinogenes, sp. n.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR WOLINELLA SUCCINOGENES
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
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    • Added: February 16, 2022