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Xiang2007
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<p>Two new <em>β</em>-class milbemycins from <em>Streptomyces bingchenggensis</em>, named milbemycin <em>β</em><sub>13</sub> and <em>β</em><sub>14</sub>, have been isolated and characterized. The producing organism has been deposited at the China General Microbiology Culture Collection Center (Accession No: CGMCC1734). On the basis of detailed spectroscopic analysis and comparison with reported data, their structures were determined to be the hydroxyl derivatives at C-27 of milbemycin <em>β</em><sub>3</sub> and 25-ethylmilbemycin <em>β</em><sub>3</sub>, respectively. Milbemycins <em>β</em><sub>13</sub> and <em>β</em><sub>14</sub> possess potent acaricidal and nematocidal activity. The discovery of these two compounds plays an important role in understanding and perfecting the proposed pathways of milbemycins.</p>
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